Dry needling has various, well-documented positive effects on the body including increased blood flow, reduced inflammation, improved tissue healing, desensitization of peripheral and central pain mechanisms and activation of the body’s pain modulation systems (reduction of pain), reduced inflammatory markers, and improved endocrine function. The physiological effects of needling are significant, and the literature/evidence suggests that dry needling can serve as an extremely effective therapeutic intervention for various musculoskeletal pain syndromes with extremely good outcomes.